In enzymology, aldose-6-phosphate reductase (NADPH) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-sorbitol 6-phosphate and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are D-glucose 6-phosphate (shown in open-chain aldehydo form), reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-aldose-6-phosphate:NADP<sup>+</sup> 1-oxidoreductase. Other names in common use include aldose 6-phosphate reductase, NADP<sup>+</sup>-dependent aldose 6-phosphate reductase, A6PR, aldose-6-P reductase, aldose-6-phosphate reductase, alditol 6-phosphate:NADP<sup>+</sup> 1-oxidoreductase, and aldose-6-phosphate reductase (NADPH).