2-hydroxyethylphosphonate dioxygenase (, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O<sub>2</sub> 1,2-oxidoreductase (hydroxymethylphosphonate forming). This enzyme catalyses the following chemical reaction
2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II) and is involved in the biosynthesis of phosphinothricin.