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List of EC numbers (EC 3)

This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 3.1: Acting on Ester Bonds

EC 3.1.1: Carboxylic Ester Hydrolases

EC 3.1.2: Thioester Hydrolases

EC 3.1.3: Phosphoric Monoester Hydrolases

EC 3.1.4: Phosphoric Diester Hydrolases

EC 3.1.5: Triphosphoric Monoester Hydrolases

EC 3.1.6: Sulfuric Ester Hydrolases

EC 3.1.7: Diphosphoric Monoester Hydrolases

EC 3.1.8: Phosphoric Triester Hydrolases

EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters

EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters

EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters

EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters

EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters

EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters

EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters

EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5

Deleted sub-subclasses.

EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases

EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters

EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters

  • EC 3.1.27.1: Now , ribonuclease T<sub>2</sub>, since the primary reaction is that of a lyase
  • EC 3.1.27.2: Now , Bacillus subtilis ribonuclease, since the reaction catalysed is that of a lyase
  • EC 3.1.27.3: Now , ribonuclease T<sub>1</sub>, since the primary reaction is that of a lyase
  • EC 3.1.27.4: Now , ribonuclease U<sub>2</sub>, since the primary reaction is that of a lyase
  • EC 3.1.27.5: Now , pancreatic ribonuclease.
  • EC 3.1.27.6: Now , Enterobacter ribonuclease, since the primary reaction is that of a lyase
  • : ribonuclease F
  • : ribonuclease V
  • EC 3.1.27.9: Now , tRNA-intron lyase
  • EC 3.1.27.10: Now , ribotoxin,

EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters

EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters

EC 3.2: Glycosylases

EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds

EC 3.2.2: Hydrolysing N-Glycosyl Compounds

EC 3.2.3: Hydrolysing S-Glycosyl Compounds

Deleted sub-subclass

EC 3.3: Acting on Ether Bonds

EC 3.3.1: Thioether and trialkylsulfonium hydrolases

EC 3.3.2: Ether Hydrolases

EC 3.4: Acting on peptide bonds – Peptidase

EC 3.4.1 α-amino acyl peptide hydrolases (discontinued)

  • EC 3.4.1.1: Now , leucyl aminopeptidase
  • EC 3.4.1.2: Now , membrane alanyl aminopeptidase
  • EC 3.4.1.3: Now , tripeptide aminopeptidase
  • EC 3.4.1.4: Now , prolyl aminopeptidase

EC 3.4.2 Peptidyl amino acid hydrolases (discontinued)

  • EC 3.4.2.1: Now , carboxypeptidase A
  • EC 3.4.2.2: Now , carboxypeptidase B
  • EC 3.4.2.3: Now , Gly-Xaa carboxypeptidase

EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass)

  • EC 3.4.3.1: Now , cytosol nonspecific dipeptidase
  • EC 3.4.3.2: Now , cytosol nonspecific dipeptidase
  • EC 3.4.3.3: Now , Xaa-His dipeptidase
  • EC 3.4.3.4: Now , Xaa-methyl-His dipeptidase
  • EC 3.4.3.5: Now , membrane alanyl aminopeptidase
  • EC 3.4.3.6: Now , cytosol nonspecific dipeptidase
  • EC 3.4.3.7: Now , Xaa-Pro dipeptidase

EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued)

  • EC 3.4.4.1: Now , pepsin A
  • EC 3.4.4.2: Now , pepsin B
  • EC 3.4.4.3: Now , chymosin
  • EC 3.4.4.4: Now , trypsin
  • EC 3.4.4.5: Now , chymotrypsin
  • EC 3.4.4.6: Now , chymotrypsin
  • EC 3.4.4.7: Now covered by , pancreatic elastase and , leukocyte elastase
  • EC 3.4.4.8: Now , enteropeptidase
  • EC 3.4.4.9: Now , dipeptidyl-peptidase I
  • EC 3.4.4.10: Now , papain
  • EC 3.4.4.11: Now , chymopapain
  • EC 3.4.4.12: Now , ficain
  • EC 3.4.4.13: Now , thrombin
  • EC 3.4.4.14: Now , plasmin
  • EC 3.4.4.15: Now , renin
  • EC 3.4.4.16: Now covered by the microbial serine proteinases (subtilisin), (oryzin), (endopeptidase K), (thermomycolin), (thermitase) and (endopeptidase So)
  • EC 3.4.4.17: Now covered by the microbial aspartic proteinases (penicillopepsin), (rhizopuspepsin), (endothiapepsin), (mucorpepsin), (candidapepsin), (saccharopepsin), (rhodotorulapepsin), (physarolisin), (acrocylindropepsin), (polyporopepsin) and (pycnoporopepsin)
  • EC 3.4.4.18: Now , streptopain
  • EC 3.4.4.19: Now , microbial collagenase
  • EC 3.4.4.20: Now , clostripain
  • EC 3.4.4.21: Now (plasma kallikrein) and (tissue kallikrein)
  • EC 3.4.4.22: Now , gastricsin
  • EC 3.4.4.23: Now , cathepsin D
  • EC 3.4.4.24: Now covered by (stem bromelain) and (fruit bromelain)
  • EC 3.4.4.25: deleted

EC 3.4.11 Aminopeptidases

EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)

  • EC 3.4.12.1: Now (carboxypeptidase C) and (carboxypeptidase D)
  • EC 3.4.12.2: Now , carboxypeptidase A
  • EC 3.4.12.3: Now , carboxypeptidase B
  • EC 3.4.12.4: Now , lysosomal Pro-Xaa carboxypeptidase
  • EC 3.4.12.5: Now , N-acetylmuramoyl-<small>L</small>-alanine amidase
  • EC 3.4.12.6: Now , muramoyl-pentapeptidase carboxypeptidase
  • EC 3.4.12.7: Now , lysine carboxypeptidase
  • EC 3.4.12.8: Now , Gly-Xaa carboxypeptidase
  • EC 3.4.12.9: aspartate carboxypeptidase
  • EC 3.4.12.10: Now , γ-glutamyl hydrolase
  • EC 3.4.12.11: Now , alanine carboxypeptidase
  • EC 3.4.12.12: Now (carboxypeptidase C) and (carboxypeptidase D)
  • EC 3.4.12.13: γ-glutamylglutamate carboxypeptidase

EC 3.4.13 Dipeptidases

EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases

EC 3.4.15 Peptidyl dipeptidases

EC 3.4.16 Serine type carboxypeptidases

EC 3.4.17 Metallocarboxypeptidases

EC 3.4.18 Cysteine type carboxypeptidases

EC 3.4.19 Omega peptidases

EC 3.4.21: Serine proteases

EC 3.4.22 Cysteine proteases

EC 3.4.23 Aspartic endopeptidases

EC 3.4.24: Metallopeptidases

EC 3.4.25 Threonine endopeptidases

  • : proteasome endopeptidase complex
  • : HslU—HslV peptidase
  • EC 3.4.99.7: Deleted entry: euphorbain
  • EC 3.4.99.8: Deleted entry: Gliocladium proteinase
  • EC 3.4.99.9: Deleted entry: hurain. Now considered to be , cucumisin
  • EC 3.4.99.10: Transferred entry: insulinase. Now , insulysin
  • EC 3.4.99.11: Deleted entry: Streptomyces alkalophilic keratinase
  • EC 3.4.99.12: Deleted entry: Trichophyton mentagrophytes keratinase
  • EC 3.4.99.13: Transferred entry: β-lytic proteinase (Mycobacterium sorangium). Now , β-lytic metalloendopeptidase
  • EC 3.4.99.14: Deleted entry: mexicanain
  • EC 3.4.99.15: Deleted entry: Paecilomyces proteinase
  • EC 3.4.99.16: Deleted entry: Penicillium notatum extracellular proteinase
  • EC 3.4.99.17: Deleted entry: peptidoglycan endopeptidase
  • EC 3.4.99.18: Deleted entry: pinguinain
  • EC 3.4.99.19: Transferred entry: renin. Now , renin
  • EC 3.4.99.20: Deleted entry: scopulariopsis proteinase
  • EC 3.4.99.21: Deleted entry: solanain. Now considered , cucumisin
  • EC 3.4.99.22: Transferred entry: staphylokinase. , aureolysin
  • EC 3.4.99.23: Deleted entry: tabernamontanain. Now considered EC 3.4.21.25, cucumisin
  • EC 3.4.99.24: Deleted entry: Tenebrio α-proteinase
  • EC 3.4.99.25: Transferred entry: trametes acid proteinase. , rhizopuspepsin
  • EC 3.4.99.26: Transferred entry: urokinase. Now , t-plasminogen activator
  • EC 3.4.99.27: Deleted entry: Echis carinatus prothrombin-activating proteinase
  • EC 3.4.99.28: Transferred entry: Oxyuranus scutellatus prothrombin-activating proteinase. , scutelarin
  • EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I
  • EC 3.4.99.30: Transferred entry: Myxobacter AL-1 proteinase II. , peptidyl-Lys metalloendopeptidase
  • EC 3.4.99.31: Transferred entry: tissue endopeptidase degrading collagenase synthetic substrate. , thimet oligopeptidase
  • EC 3.4.99.32: Transferred entry: Armillaria mellea neutral proteinase. Now , peptidyl-Lys metalloendopeptidase
  • EC 3.4.99.33: Deleted entry: cathepsin R
  • EC 3.4.99.34: Deleted entry: mytilidase
  • EC 3.4.99.35: Transferred entry: premurein-leader peptidase. Now , signal peptidase II
  • EC 3.4.99.36: Transferred entry: leader peptidase. Now , signal peptidase I
  • EC 3.4.99.37: Deleted entry: RecA peptidase
  • EC 3.4.99.38: Transferred entry: pro-opiomelanotropin-converting proteinase. Now , pro-opiomelanocortin converting enzyme
  • EC 3.4.99.39: Deleted entry: pseudomurein endopeptidase
  • EC 3.4.99.40: Deleted entry: pro-gonadoliberin proteinase
  • EC 3.4.99.41: Transferred entry: mitochondrial processing peptidase. Now , mitochondrial processing peptidase
  • EC 3.4.99.42: Deleted entry: leucyllysine endopeptidase
  • EC 3.4.99.43: Transferred entry: thermopsin. Npw , thermopsin
  • EC 3.4.99.44: Transferred entry: pitrilysin. Now , pitrilysin
  • EC 3.4.99.45: Transferred entry: insulinase. Now , insulysin
  • EC 3.4.99.46: Transferred entry: multicatalytic endopeptidase complex. Now , proteasome endopeptidase complex

EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1: In linear amides

3.5.2: In cyclic amides

3.5.3: In linear amidines

3.5.4: In cyclic amidines

3.5.5: In nitriles

3.5.99: In other compounds

EC 3.6: Acting on acid anhydrides

3.6.1: In phosphorus-containing anhydrides

3.6.2: In sulfonyl-containing anhydrides

3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances

  • : phospholipid-translocating ATPase
  • EC 3.6.3.2: Now , P-type Mg<sup>2+</sup> transporter
  • EC 3.6.3.3: Now , Cd<sup>2+</sup>-exporting ATPase
  • EC 3.6.3.4: Now , Cu<sup>2+</sup>-exporting ATPase
  • EC 3.6.3.5: Now , Zn<sup>2+</sup>-exporting ATPase
  • EC 3.6.3.6: Now , P-type H<sup>+</sup>-exporting transporter
  • EC 3.6.3.7: Now , P-type Na<sup>+</sup> transporter
  • EC 3.6.3.8: Now , Ca<sup>2+</sup>-transporting ATPase
  • EC 3.6.3.9: Now , Na<sup>+</sup>/K<sup>+</sup>-exchanging ATPase
  • EC 3.6.3.10: Now , H<sup>+</sup>/K<sup>+</sup>-exchanging ATPase
  • EC 3.6.3.11: "Cl<sup>–</sup>-transporting ATPase". The activity was only ever studied in crude extracts, and is an artifact
  • EC 3.6.3.12: Now , K<sup>+</sup>-transporting ATPase
  • EC 3.6.3.13:Identical to , phospholipid-translocating ATPase
  • EC 3.6.3.14: Now , H<sup>+</sup>-transporting two-sector ATPase
  • EC 3.6.3.15: Now , Na<sup>+</sup>-transporting two-sector ATPase
  • EC 3.6.3.16: Now , arsenite-transporting ATPase
  • EC 3.6.3.17: Now covered by various ABC-type monosaccharide transporters in sub-subclass EC 7.5.2
  • EC 3.6.3.18: Now , ABC-type oligosaccharide transporter
  • EC 3.6.3.19: Now , ABC-type maltose transporter
  • EC 3.6.3.20: Now , glycerol-3-phosphate-transporting ATPase
  • EC 3.6.3.21: Now , ABC-type polar-amino-acid transporter
  • EC 3.6.3.22: Now , ABC-type nonpolar-amino-acid transporter
  • EC 3.6.3.23: Now , oligopeptide-transporting ATPase
  • EC 3.6.3.24: Now , nickel-transporting ATPase
  • EC 3.6.3.25: Now , sulfate-transporting ATPase
  • EC 3.6.3.26: Now , nitrate-transporting ATPase
  • EC 3.6.3.27: Now , ABC-type phosphate transporter
  • EC 3.6.3.28: Now , ABC-type phosphonate transporter
  • EC 3.6.3.29: Now , molybdate-transporting ATPase
  • EC 3.6.3.30: Now , Fe<sup>3+</sup>-transporting ATPase
  • EC 3.6.3.31: Now , polyamine-transporting ATPase
  • EC 3.6.3.32: Now , quaternary-amine-transporting ATPase
  • EC 3.6.3.33: Now , vitamin B<sub>12</sub>-transporting ATPase
  • EC 3.6.3.34: now recognized to be at least three separate enzymes , iron(III) hydroxamate ABC transporter, , ferric enterobactin ABC transporter, and , ferric citrate ABC transporter
  • EC 3.6.3.35: Now , manganese-transporting ATPase
  • EC 3.6.3.36: Now , taurine-transporting ATPase
  • EC 3.6.3.37: Now , guanine-transporting ATPase
  • EC 3.6.3.38: Now , ABC-type capsular-polysaccharide transporter
  • EC 3.6.3.39: Now , lipopolysaccharide-transporting ATPase
  • EC 3.6.3.40: Now , teichoic-acid-transporting ATPase
  • EC 3.6.3.41: Now , heme-transporting ATPase
  • EC 3.6.3.42: Now , β-glucan-transporting ATPase
  • EC 3.6.3.43: Now , peptide-transporting ATPase
  • EC 3.6.3.44: Now , ABC-type xenobiotic transporter
  • EC 3.6.3.45: Now included with , xenobiotic-transporting ATPase
  • EC 3.6.3.46: Now , ABC-type Cd<sup>2+</sup> transporter
  • EC 3.6.3.47: Now , fatty-acyl-CoA-transporting ATPase
  • EC 3.6.3.48: Now as α-factor-pheromone transporting ATPase
  • EC 3.6.3.49: Now , channel-conductance-controlling ATPase
  • EC 3.6.3.50: Now , protein-secreting ATPase
  • EC 3.6.3.51: Now , mitochondrial protein-transporting ATPase
  • EC 3.6.3.52: Now , chloroplast protein-transporting ATPase
  • EC 3.6.3.53: Now , Ag<sup>+</sup>-exporting ATPase
  • EC 3.6.3.54: Now , Cu<sup>+</sup>-exporting ATPase
  • EC 3.6.3.55: Now , tungstate-importing ATPase

3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement

3.6.5: Acting on GTP to facilitate cellular and subcellular movement

EC 3.7: Acting on carbon-carbon bonds

EC 3.7.1: In ketonic substances

EC 3.8: Acting on halide bonds

EC 3.8.1: Acting on halide bonds

3.8.2: In phosphorus-halide compounds (deleted sub-subclass)

  • EC 3.8.2.1: Now , diisopropyl-fluorophosphatase

EC 3.9: act on phosphorus-nitrogen bonds

EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)

EC 3.10: Acting on sulfur-nitrogen bonds

EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

EC 3.11: Acting on carbon-phosphorus bonds

EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date)

EC 3.12: Acting on sulfur-sulfur bonds

EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date)

EC 3.13: Acting on carbon-sulfur bonds

EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date)

References