Prepilin peptidase

Prepilin peptidase () is an enzyme found in Type IV filament systems responsible for the maturation of the pilin. This enzyme catalyses the following chemical reaction

Typically cleaves a -Gly-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-<small>L</small>-methionine.

This enzyme is present on the surface of many species of bacteria. All known enzymes with this activity are of the MEROPS family A24.

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