Trimerelysin II (, Trimeresurus metalloendopeptidase II, proteinase H2, H2-proteinase) is an enzyme. This enzyme catalyses the following chemical reaction
Cleavage of Asn<sup>3</sup>-Gln, His<sup>10</sup>-Leu and Ala<sup>14</sup>-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase