The enzyme histidinol-phosphatase (EC 3.1.3.15) catalyzes the reaction
This enzyme participates in histidine metabolism.
This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name is <small>L</small>-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, <small>L</small>-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase.
In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.