In enzymology, a CDP-glycerol diphosphatase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CDP-glycerol and H<sub>2</sub>O, whereas its two products are CMP and sn-glycerol 3-phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is CDP-glycerol phosphoglycerohydrolase. Other names in common use include CDP-glycerol pyrophosphatase, and cytidine diphosphoglycerol pyrophosphatase. This enzyme participates in glycerophospholipid metabolism.