2-haloacid dehalogenase (configuration-retaining) (, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining). This enzyme catalyses the following chemical reaction
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.