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Diadenosine hexaphosphate hydrolase (ATP-forming)

Diadenosine hexaphosphate hydrolase (ATP-forming) (, Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming). This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H<sub>2</sub>O 2 ATP
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H<sub>2</sub>O ATP + ADP
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H<sub>2</sub>O ATP + AMP

The enzyme requires the presence of the divalent cations (Mn<sup>2+</sup>, Mg<sup>2+</sup>, Zn<sup>2+</sup>, and Co<sup>2+</sup>).

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