Picornain 2A (, picornavirus endopeptidase 2A, poliovirus protease 2A, rhinovirus protease 2A, 2A protease, 2A proteinase, protease 2A, proteinase 2Apro, picornaviral 2A proteinase, Y-G proteinase 2A, poliovirus proteinase 2A, poliovirus protease 2Apro) is a protease enzyme. This enzyme catalyses selective cleavage of Tyr-Gly bond in picornavirus polyprotein.
This enzyme is coded by entero-, rhino-, aphto- and cardioviruses.