In enzymology, a CDP-diacylglycerol diphosphatase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CDP-diacylglycerol and H<sub>2</sub>O, whereas its two products are CMP and phosphatidate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is CDP-diacylglycerol phosphatidylhydrolase. Other names in common use include cytidine diphosphodiacylglycerol pyrophosphatase, and CDP diacylglycerol hydrolase. This enzyme participates in glycerophospholipid metabolism.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .