Acrocylindropepsin (, Acrocylindrium proteinase, Acrocylindrium acid proteinase) is an enzyme. This enzyme catalyses the following chemical reaction
Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6-Cys(SO<sub>3</sub>H), Glu<sup>21</sup>-Arg and Asn<sup>3</sup>-Gln, although not Gln<sup>4</sup>-His
This enzyme is present in fungus Acrocylindrium sp.
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