C5a peptidase (, streptococcal C5a peptidase, ScpA, ScpB, SCPA) is an enzyme. The primary cleavage site is at His<sup>67</sup>-Lys<sup>68</sup> in human C5a with a minor secondary cleavage site at Ala<sup>58</sup>-Ser<sup>59</sup>.
This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate preference.