In enzymology, a phosphonopyruvate hydrolase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 3-phosphonopyruvate and H<sub>2</sub>O, whereas its two products are pyruvate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is . This enzyme is also called PPH.