The enzyme acyl-CoA hydrolase () catalyzes the reaction
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .