Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase

phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase, known also as Cyclic phosphate dihydrolase is a hydrolase enzyme found in various species of bacteria. The enzyme uses water to catalyze the hydrolysis of a cyclic ribophosphate to form alpha-D-ribose 1,5-bisphosphate. Formally, the enzyme catalyzes the following chemical reactions,

In Eggerthella lenta, Gordonibacter urolithinfaciens and Gordonibacter pamelaeae, the enzyme is encoded by the gene phnPP. The protein consists of 252 amino acids. The enzyme is known to have metal-ion binding sites for Mn²⁺ and Zn²⁺. The enzyme is involved in the catabolism of organophosphonates.

References