The enzyme <small>L</small>-rhamnono-1,4-lactonase (EC 3.1.1.65) catalyzes the reaction
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is <small>L</small>-rhamnono-1,4-lactone lactonohydrolase. Other names in common use include <small>L</small>rhamno-ó-lactonase, <small>L</small>-rhamnono-ó-lactonase, and <small>L</small>-rhamnonate dehydratase. This enzyme participates in fructose and mannose metabolism.