ADAMTS-4 endopeptidase (, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction
Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu<sup>373</sup>-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan
This enzyme belongs to the peptidase family M12.
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