Macrophage elastase (, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme. This enzyme catalyses the following chemical reaction
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala<sup>14</sup>-Leu- and -Tyr<sup>16</sup>-Leu- in the B chain of insulin