This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.
EC 6.1: Forming Carbon-Oxygen Bonds
EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)
EC 6.1.2: AcidâÂÂalcohol ligases (ester synthases)
EC 6.1.3: Cyclo-ligases
EC 6.2: Forming Carbon-Sulfur Bonds
EC 6.2.1: Acid-Thiol Ligases
- : acetateâÂÂCoA ligase
- : medium-chain acyl-CoA ligase
- : long-chain-fatty-acidâÂÂCoA ligase
- : succinateâÂÂCoA ligase (GDP-forming)
- : succinateâÂÂCoA ligase (ADP-forming)
- : glutarateâÂÂCoA ligase
- : cholateâÂÂCoA ligase
- : oxalateâÂÂCoA ligase
- : malateâÂÂCoA ligase
- : carboxylic acidâÂÂCoA ligase (GDP-forming)
- : biotinâÂÂCoA ligase
- : 4-coumarateâÂÂCoA ligase
- : acetateâÂÂCoA ligase (ADP-forming)
- : 6-carboxyhexanoateâÂÂCoA ligase
- : arachidonateâÂÂCoA ligase
- : acetoacetateâÂÂCoA ligase
- : propionateâÂÂCoA ligase
- : citrateâÂÂCoA ligase
- : long-chain-fatty-acidâÂÂprotein ligase
- : long-chain-fatty-acidâÂÂ[acyl-carrier-protein] ligase
- EC 6.2.1.21: Activity covered by , phenylacetateâÂÂCoA ligase
- : [citrate (pro-3S)-lyase] ligase
- : dicarboxylateâÂÂCoA ligase
- : phytanateâÂÂCoA ligase
- : benzoateâÂÂCoA ligase
- : o-succinylbenzoateâÂÂCoA ligase
- : 4-hydroxybenzoateâÂÂCoA ligase
- : 3ñ,7ñ-dihydroxy-5ò-cholestanateâÂÂCoA ligase
- EC 6.2.1.29: Deleted, identical to , cholateâÂÂCoA ligase
- : phenylacetateâÂÂCoA ligase
- : 2-furoateâÂÂCoA ligase
- : anthranilateâÂÂCoA ligase
- : 4-chlorobenzoateâÂÂCoA ligase
- : trans-feruloylâÂÂCoA synthase
- :
- : 3-hydroxypropionyl-CoA synthase
- : 3-hydroxybenzoateâÂÂCoA ligase
- : (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
- : [butirosin acyl-carrier protein]âÂÂ<small>L</small>-glutamate ligase
- : 4-hydroxybutyrateâÂÂCoA ligase (AMP-forming)
- : 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoateâÂÂCoA ligase
- : 3-oxocholest-4-en-26-oateâÂÂCoA ligase
- : 2-hydroxy-7-methoxy-5-methyl-1-naphthoateâÂÂCoA ligase
- : 3-(methylthio)propionylâÂÂCoA ligase
- : E1 ubiquitin-activating enzyme
- : <small>L</small>-allo-isoleucineâÂÂholo-[CmaA peptidyl-carrier protein] ligase
- : medium-chain-fatty-acidâÂÂ[acyl-carrier-protein] ligase
- : carnitineâÂÂCoA ligase
- : long-chain fatty acid adenylyltransferase FadD28
- : 4-hydroxybenzoate adenylyltransferase FadD22
- : 4-hydroxyphenylalkanoate adenylyltransferase FadD29
- : <small>L</small>-firefly luciferinâÂÂCoA ligase
- : <small>L</small>-prolineâÂÂ[<small>L</small>-prolyl-carrier protein] ligase
- : <small>D</small>-alanineâÂÂ[<small>D</small>-alanyl-carrier protein] ligase
- : E1 SAMP-activating enzyme
- : 4-hydroxybutyrateâÂÂCoA ligase (ADP-forming)
- : long-chain fatty acid adenylase/transferase FadD23
- : isophthalateâÂÂCoA ligase
- : long-chain fatty acid adenylase/transferase FadD26
- : marinolic acidâÂÂCoA ligase
- : salicylateâÂÂ[aryl-carrier protein] ligase
- : 3,4-dihydroxybenzoateâÂÂ[aryl-carrier protein] ligase
- : <small>L</small>-arginineâÂÂ[<small>L</small>-arginyl-carrier protein] ligase
- : E1 NEDD8-activating enzyme
- : salicylateâÂÂCoA ligase
- : glyineâÂÂ[glycyl-carrier protein] ligase
- : <small>L</small>-alanineâÂÂ[<small>L</small>-alanyl-carrier protein] ligase
- : <small>L</small>-glutamateâÂÂ[<small>L</small>-glutamyl-carrier protein] ligase
- : <small>L</small>-cysteineâÂÂ[<small>L</small>-cysteinyl-carrier protein] ligase
- : <small>L</small>-threonineâÂÂ[<small>L</small>-threonyl-carrier protein] ligase
- : 2,3-dihydroxybenzoateâÂÂ[aryl-carrier protein] ligase
- : <small>L</small>-serineâÂÂ[<small>L</small>-seryl-carrier protein] ligase
- : <small>L</small>-tryptophanâÂÂ[<small>L</small>-tryptophyl-carrier protein] ligase
- : 3-amino-5-hydroxybenzoateâÂÂ[acyl-carrier protein] ligase
- : indoleacetateâÂÂCoA ligase
- : malonateâÂÂCoA ligase *
EC 6.2.2: AmideâÂÂthiol ligases
EC 6.3: Forming Carbon-Nitrogen Bonds
EC 6.3.1: AcidâÂÂAmmonia (or Amine) Ligases (Amide Synthases)
EC 6.3.2: AcidâÂÂAmino-Acid Ligases (Peptide Synthases)
- : pantoateâÂÂò-alanine ligase (AMP-forming)
- : glutamateâÂÂcysteine ligase
- : glutathione synthase
- : <small>D</small>-alanineâÂÂ<small>D</small>-alanine ligase
- : phosphopantothenateâÂÂcysteine ligase (CTP)
- : phosphoribosylaminoimidazolesuccinocarboxamide synthase
- : UDP-N-acetylmuramoyl-<small>L</small>-alanyl-<small>D</small>-glutamateâÂÂ<small>L</small>-lysine ligase
- : UDP-N-acetylmuramateâÂÂ<small>L</small>-alanine ligase
- : UDP-N-acetylmuramoyl-<small>L</small>-alanineâÂÂ<small>D</small>-glutamate ligase
- : UDP-N-acetylmuramoyl-tripeptideâÂÂ<small>D</small>-alanyl-<small>D</small>-alanine ligase
- : carnosine synthase
- : dihydrofolate synthase
- : UDP-N-acetylmuramoyl-<small>L</small>-alanyl-<small>D</small>-glutamateâÂÂ2,6-diaminopimelate ligase
- : enterobactin synthase
- EC 6.3.2.15: Deleted, The activity observed is due to , UDP-N-acetylmuramoyl-tripeptide<small>D</small>-alanyl-<small>D</small>-alanine ligase
- : <small>D</small>-alanineâÂÂalanyl-poly(glycerolphosphate) ligase
- : tetrahydrofolate synthase
- : ó-glutamylhistamine synthase
- EC 6.3.2.19: The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of (E2 ubiquitin-conjugating enzyme) and (RING-type E3 ubiquitin transferase)
- : indoleacetateâÂÂlysine synthetase
- EC 6.3.2.21: The reaction is performed by the sequential action of (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by [ubiquitin transferase RING E3 (calmodulin-selective)]
- EC 6.3.2.22: Now , diphthineâÂÂammonia ligase.
- : homoglutathione synthase
- : tyrosineâÂÂarginine ligase
- : tubulinâÂÂtyrosine ligase
- : N-(5-amino-5-carboxypentanoyl)-<small>L</small>-cysteinyl-<small>D</small>-valine synthase
- EC 6.3.2.27: The activity is covered by two independent enzymes, N<sup>2</sup>-citryl-N<sup>6</sup>-acetyl-N<sup>6</sup>-hydroxylysine synthase, and , aerobactin synthase
- EC 6.3.2.28: Now , <small>L</small>-alanine-<small>L</small>-anticapsin ligase
- : cyanophycin synthase (<small>L</small>-aspartate-adding)
- : cyanophycin synthase (<small>L</small>-arginine-adding)
- :
- :
- : tetrahydrosarcinapterin synthase
- :
- : <small>D</small>-alanineâÂÂ<small>D</small>-serine ligase
- : 4-phosphopantoateâÂÂò-alanine ligase
- : UDP-N-acetylmuramoyl-<small>L</small>-alanyl-<small>D</small>-glutamateâÂÂ<small>D</small>-lysine ligase
- : N<sup>2</sup>-citryl-N<sup>6</sup>-acetyl-N<sup>6</sup>-hydroxylysine synthase
- : aerobactin synthase
- : cyclopeptine synthase
- : N-acetylaspartylglutamate synthase
- : synthase
- : [amino-group carrier protein]âÂÂ<small>L</small>-2-aminoadipate ligase
- : pantoateâÂÂò-alanine ligase (ADP-forming)
- : UDP-N-acetylmuramateâÂÂ<small>L</small>-alanyl-ó-<small>D</small>-glutamyl-meso-2,6-diaminoheptanedioate ligase
- : fumarateâÂÂ(S)-2,3-diaminopropanoate ligase
- : dapdiamide synthase
- : <small>L</small>-arginine-specific <small>L</small>-amino acid ligase
- : <small>L</small>-alanineâÂÂ<small>L</small>-anticapsin ligase
- : tenuazonic acid synthetase
- : phosphopantothenateâÂÂcysteine ligase (ATP)
- : jasmonoylâÂÂ<small>L</small>-amino acid ligase
- : UDP-N-acetylmuramoyl-<small>L</small>-alanineâÂÂ<small>L</small>-glutamate ligase
- : <small>L</small>-2,3-diaminopropanoateâÂÂcitrate ligase
- : 2-[(<small>L</small>-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
- : staphyloferrin B synthase
- : staphyloferrin A synthase
- : <small>D</small>-ornithineâÂÂcitrate ligase
- : 3-methyl-<small>D</small>-ornithineâÂÂ<small>L</small>-lysine ligase
- : glutamateâÂÂ[amino group carrier protein] ligase
- : tubulin-glutamate ligase
- : ò-tubulin-glutamate ligase
EC 6.3.3: Cyclo-Ligases
EC 6.3.4: Other Carbon-Nitrogen Ligases
EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-N-donor
EC 6.4: Forming Carbon-Carbon Bonds
EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
EC 6.5: Forming Phosphoric Ester Bonds
EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
EC 6.6: Forming Nitrogen-Metal Bonds
EC 6.6.1: Forming Coordination Complexes
EC 6.7: Forming nitrogen-nitrogen bonds
EC 6.7.1: Forming diazo bonds
References