In enzymology, a ribose-5-phosphateâÂÂammonia ligase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH<sub>3</sub>, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). This enzyme participates in purine metabolism.