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Biotin—(methylmalonyl-CoA-carboxytransferase) ligase

In enzymology, a biotin—[methylmalonyl-CoA-carboxytransferase] ligase () is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]

The 3 substrates of this enzyme are ATP, biotin, and ], whereas its 3 products are AMP, diphosphate, and .

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming). This enzyme participates in biotin metabolism.

References