In enzymology, an asparagineâÂÂtRNA ligase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are ATP, -asparagine, and tRNA, whereas its 3 products are AMP, diphosphate, and -asparaginyl-tRNA.
This enzyme belongs to the family of ligases, to be specific those forming carbonâÂÂoxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is -asparagine:tRNA ligase (AMP-forming). Other names in common use include asparaginyl-tRNA synthetase, asparaginyl-transfer ribonucleate synthetase, asparaginyl transfer RNA synthetase, asparaginyl transfer ribonucleic acid synthetase, asparagyl-transfer RNA synthetase, and asparagine translase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .