Cyclopeptine synthase () is an enzyme that catalyzes the chemical reaction
anthranilate + L-phenylalanine + S-adenosyl-L-methionine + 2 ATP cyclopeptine + 2 AMP + S-adenosyl-L-homocysteine + 2 diphosphate + 2 H(+)
In Penicillium cyclopium, cyclopeptine synthase is important for benzodiazepine alkaloid biosynthesis.
Enzyme Classification History
Formerly, cyclopentine synthase activity was classified under two separate enzymes.
- anthranilate adenylyltransferase () catalyzes the partial reaction
ATP + anthranilate diphosphate + N-adenylylanthranilate
- phenylalanine adenylyltransferase () catalyzes the partial reaction
ATP + L-phenylalanine diphosphate + N-adenylyl-L-phenylalanine
and were reclassified and merged into .
References