Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine. It acts as a selective ñ<sub>1</sub>-adrenergic receptor agonist. Desglymidodrine is formed from midodrine via deglycination.
The elimination half-life of desglymidodrine is 2 to 4hours.
Desglymidodrine, also known as 3,6-dimethoxy-ò-hydroxy-2-phenylethylamine, is a substituted phenethylamine derivative.
Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95. The predicted log P of desglymidodrine ranges from -0.01 to 0.15.
An analogue of desglymidodrine is dimetofrine (3,5-dimethoxy-4,ò-dihydroxy-N-methylphenethylamine).