Dimetofrine (), also known as dimethophrine or dimetophrine and sold under the brand names Dovida, Pressamina, and Superten, is a medication described as a sympathomimetic, vasoconstrictor, and cardiac stimulant. It is said to be similarly or less effective than midodrine in the treatment of orthostatic hypotension and shows substantially lower potency.
The drug is a selective ñ<sub>1</sub>-adrenergic receptor agonist but is also said to have ò-adrenergic receptor agonist activity. It is a substituted phenethylamine and is also known as 3,5-dimethoxy-4,ò-dihydroxy-N-methylphenethylamine. Its chemical structure is similar to that of desglymidodrine (3,6-dimethoxy-ò-hydroxyphenethylamine), the active metabolite of midodrine.
Dimetofrine remained marketed only in Italy in 2000.