List of opioids

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Crude opiate extracts whole opium products

• B&O Supprettes
• Diascordium
• Dover's powder
• Kendal Black Drop
• Laudanum
• Mithridate
• Opium
• Polish heroin (Compote, Kompot)
• Paregoric
• Poppy straw concentrate
• Poppy tea
• Smoking opium
• Theriac

Natural opiates

Opium alkaloids

• Codeine
• Morphine
• Oripavine
• Pseudomorphine
• Thebaine

Alkaloid salts mixtures

• Pantopon
• Papaveretum (Omnopon)
• Tetrapon

Semisynthetics including Bentley compounds

Morphine family

• 14-Hydroxymorphine 
• 2,4-Dinitrophenylmorphine
• 6-Methyldihydromorphine 
• 6-Methylenedihydrodesoxymorphine
• 6-Acetyldihydromorphine 
• Azidomorphine
• Chlornaltrexamine
• Chloroxymorphamine 
• Desomorphine (dihydrodesoxymorphine)
• Dihydromorphine
• Ethyldihydromorphine 
• Hydromorphinol
• Methyldesorphine
• Morphine methylbromide
• N-Phenethylnordesomorphine
• N-Phenethyl-14-ethoxymetopon
• N-Phenethylnormorphine
• 6-Nicotinoyldihydromorphine (metabolite of nicodicodeine)
• RAM-378
• Ro4-1539

3,6-diesters of morphine

• Acetylpropionylmorphine
• 3,6-Dibutanoylmorphine
• Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
• Dibutyrylmorphine https://pubchem.ncbi.nlm.nih.gov/substance/749322
• Dibenzoylmorphine (first designer drug)
• Diformylmorphine 
• Dipropanoylmorphine
• Heroin (diacetylmorphine)
• Nicomorphine

Codeine-dionine family

• 6-Monoacetylcodeine
• Benzylmorphine
• Codeine methylbromide
• Desocodeine http://www.chembase.com/cbid_346212.htm
• Dimethylmorphine (6-O-Methylcodeine) 
• Ethyldihydromorphine http://www.chembase.com/cbid_346222.htm
• Methyldihydromorphine (dihydroheterocodeine)
• Ethylmorphine (dionine)
• Heterocodeine
• Isocodeine http://www.tradingchem.com/Isocodeine/509-64-8.html
• Pholcodine (morpholinylethylmorphine)
• Myrophine
• Thebacon
• Transisocodeine https://pubchem.ncbi.nlm.nih.gov/compound/5493070

Morphinones and morphols

• 14-Cinnamoyloxycodeinone
• 14-Ethoxymetopon
• 14-Methoxymetopon
• 14-Phenylpropoxymetopon
• 3-Acetyloxymorphone
• 3,14-Diacetyloxymorphone
• 7-Spiroindanyloxymorphone
• 8,14-Dihydroxydihydromorphinone http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1959-01-01_3_page002.html
• Acetylcodone 
• Acetylmorphone
• α-hydrocodol  (=dihydrocodeine, )
• Benzhydrocodone
• Bromoisopropropyldihydromorphinone cas?
• Codeinone
• Codoxime
• Conorfone (codorphone)
• IBNtxA
• Thebacon (acetyldihydrocodeinone, dihydrocodeinone enol acetate)
• Hydrocodone
• Hydromorphone
• Hydroxycodeine http://www.tradingchem.com/Search/1777-89-5.html
• Metopon (=methyldihydromorphinone)
• Morphenol http://www.tradingchem.com/Search/519-56-2.html
• Morphinone
• Morphol http://www.tradingchem.com/Morphol/478-71-7.html
• N-Phenethyl-14-ethoxymetopon
• Noroxymorphone
• Oxycodone
• Oxymorphol
• Oxymorphone
• Pentamorphone
• Semorphone
• 14-Hydroxycodeine

Morphides

• α-Chlorocodide (= chlorocodide) https://web.archive.org/web/20140729114731/http://chemlookup.com/CAS_Number/467-08-3.html
• β-Chlorocodide https://web.archive.org/web/20140729115454/http://chemlookup.com/CAS_Number/466-95-5.html
• α-Chloromorphide (= chloromorphide)
• Bromocodide https://archive.today/20130119000155/http://chemlookup.com/CAS_Number/6339-42-0.html
• Bromomorphide https://archive.today/20130120001232/http://chemlookup.com/CAS_Number/63732-46-7.html
• Chlorodihydrocodide https://web.archive.org/web/20160304082931/http://chemlookup.com/CAS_Number/63690-27-7.html
• Chloromorphide
• Codide  https://archive.today/20130119024654/http://chemlookup.com/CAS_Number/5121-66-4.html

Dihydrocodeine series

• 14-Hydroxydihydrocodeine
• Acetyldihydrocodeine
• Dihydrocodeine
• Dihydrodesoxycodeine (desocodeine) 
• Dihydroisocodeine 
• Nicocodeine
• Nicodicodeine

Nitrogen morphine derivatives

• 1-Nitrocodeine cas? https://books.google.com/books?id=KTWoPZdOwQAC&pg=PA33
• Codeine-N-oxide https://pubchem.ncbi.nlm.nih.gov/compound/5359929
• Morphine-N-oxide

Hydrazones

• Oxymorphazone

Halogenated morphine derivatives

• 1-Bromocodeine 
• 1-Chlorocodeine 
• 1-Iodomorphine

Active opiate metabolites

• Codeine-6-glucuronide 
• Codeine-N-oxide (genocodeine)https://archive.today/20130119055411/http://chemlookup.com/CAS_Number/3688-65-1.html
• Heroin-7,8-oxide https://archive.today/20130119043408/http://chemlookup.com/CAS_Number/77632-95-2.html
• Morphine-6-glucuronide
• 3-Monoacetylmorphine
• 6-Monoacetylmorphine
• Morphine-N-oxide (genomorphine)
• Naltrexol https://pubchem.ncbi.nlm.nih.gov/compound/5486554
• Norcodeine 
• Normorphine

Morphinans

Morphinan series

• 3-Hydroxymorphinan 
• 4-Chlorophenylpyridomorphinan https://books.google.com/books?id=h0hpnxaostYC&pg=PA39
• Cyclorphan
• Levargorphan http://isomerdesign.com/Cdsa/schedule.php?schedule=1&section=10&structure=U&structure=C
• Levorphanol
• Levophenacylmorphan
• Levomethorphan
• Methorphan (racemethorphan)
• Morphanol (racemorphanol)
• Norlevorphanol
• N-Methylmorphinan http://www.chemspider.com/Chemical-Structure.20052868.html
• Oxilorphan
• Phenomorphan
• Proxorphan
• Ro4-1539
• Stephodeline http://research.rdi.ku.ac.th/world/cache/31/ArthitMAKAll.pdf Xorphanol

Others

• 1-Nitroaknadinine * 14-episinomenine 
• 5,6-Dihydronorsalutaridine 
• 6-Keto Nalbuphine 
• Aknadinine 
• Butorphanol
• Cephakicine 
• Cephasamine 
• Cyprodime
• Drotebanol
• Fenfangjine G 
• Ketorfanol
• Nalbuphine
• Nalbuphone
• Tannagine

Benzomorphans

• 5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB) http://www.nextbio.com/b/search/details/5%2C9-DEHB?id=324611&type=compound
• 8-Carboxamidocyclazocine (8-CAC)
• Alazocine
• Anazocine http://www.chemnet.com/cas/supplier.cgi?terms=15378-99-1&l=en&exact=dict&f=plist&mark=&submit.x=41&submit.y=13
• Bremazocine
• Butinazocine http://www.chemnet.com/cas/en/93821-75-1/Butinazocine.html
• Carbazocine http://www.chemnet.com/cas/supplier.cgi?terms=Carbazocine&l=en&exact=dict&f=plist&mark=&submit.x=21&submit.y=10
• Cogazocine
• Cyclazocine
• Dezocine
• Eptazocine
• Etazocine http://www.chembase.com/cbid_31037.htm
• Ethylketazocine https://pubchem.ncbi.nlm.nih.gov/compound/135018
• Fedotozine 
• Fluorophen https://pubchem.ncbi.nlm.nih.gov/compound/3036297
• Gemazocine http://www.chembase.com/cbid_219096.htm
• Ibazocine http://chembase.com/cbid_216286.htm
• Ketazocine
• Metazocine
• Moxazocine  https://pubchem.ncbi.nlm.nih.gov/compound/3047776
• Pentazocine
• Phenazocine
• Quadazocine https://pubchem.ncbi.nlm.nih.gov/compound/115077
• SKF-10047
• Tonazocine
• Volazocine
• Zenazocinehttp://www.nextbio.com/b/search/details/zenazocine%20hydrochloride,%20%282S-%282alpha,6alpha,11S*%29%29-isomer?id=351655&type=compound

4-Phenylpiperidines

Pethidines (meperidines)

• 4-Fluoropethidine
• Allylnorpethidine
• Anileridine
• Benzethidine
• Carperidine
• Difenoxin
• Diphenoxylate
• Etoxeridine (carbetidine)
• Furethidine
• Hydroxypethidine (bemidone)
• Morpheridine
• Meperidine-N-oxide 
• Oxpheneridine (carbamethidine)
• Pethidine (meperidine)
• Pethidine intermediate A
• Pethidine intermediate B (norpethidine)
• Pethidine intermediate C (pethidinic acid)
• Pheneridine
• Phenoperidine
• Piminodine
• Properidine (ipropethidine)
• Sameridine

Prodines

• Allylprodine
• (α/β)-Meprodine
• Desmethylprodine (MPPP)
• PEPAP
• (α/β)-Prodine
• Prosidol
• Trimeperidine (promedol)

Ketobemidones

• Acetoxyketobemidone
• Droxypropine
• Ketobemidone
• Methylketobemidone
• Propylketobemidone

Others

• Alvimopan
• Loperamide
• LS-115509
• Picenadol

Open chain opioids

Amidones

• Dextromethadone 
• Dipipanone
• Dipyanone
• Isomethadone
• Levoisomethadone 
• Levomethadone 
• Methadone
• Methadone intermediate https://web.archive.org/web/20120426080102/http://forendex.southernforensic.org/index.php/detail/index/125
• Normethadone
• Norpipanone http://mtnviewfarm.net/drugs-poisons-1203.html
• Phenadoxone (heptazone)

Methadols

• Acetylmethadol 
• Alphaacetylmethadol 
• Alphamethadol 
• Betacetylmethadol 
• Betamethadol 
• Dimepheptanol (racemethadol)
• Isomethadol 
• Levacetylmethadol
• Noracymethadol

Moramides

• Desmethylmoramide 
• Dextromoramide
• Levomoramide
• Moramide intermediate  http://isomerdesign.com/Cdsa/scheduleUS.php?schedule=2&section=3&structure=U&structure=C
• Racemoramide

Thiambutenes

• Diethylthiambutene
• Dimethylthiambutene
• Ethylmethylthiambutene
• Piperidylthiambutene
• Pyrrolidinylthiambutene
• Thiambutene

Phenalkoxams

• Dextropropoxyphene (propoxyphene)
• Dimenoxadol
• Dioxaphetyl butyrate
• Levopropoxyphene
• Norpropoxyphene
• Pyrroliphene

Ampromides

• Diampromide
• Phenampromide
• Propiram

Others

• Embutramide
• IC-26
• Isoaminile
• Lefetamine
• R-4066

Anilidopiperidines

• 3-Allylfentanyl
• 3-Methylfentanyl
• 3-Methylthiofentanyl
• 4-Phenylfentanyl
• Alfentanil
• α-Methylacetylfentanyl
• α-Methylfentanyl
• α-Methylthiofentanyl
• Benzylfentanyl  https://www.ncbi.nlm.nih.gov/pccompound?cmd=search&term=73859 
• β-hydroxyfentanyl
• β-hydroxythiofentanyl
• β-Methylfentanyl
• Brifentanil
• Butyrfentanyl
• Carfentanil
• Fentanyl
• Lofentanil
• N-Methylcarfentanil
• Mirfentanil
• Ocfentanil
• Ohmefentanyl
• Parafluorofentanyl
• Phenaridine
• R-30490
• Remifentanil
• Sufentanil
• Thenylfentanyl https://web.archive.org/web/20120426081041/http://forendex.southernforensic.org/index.php/detail/index/478
• Thiofentanyl
• Trefentanil

Oripavine derivatives

• 7-PET
• Acetorphine
• Alletorphine (N-allyl-noretorphine)
• BU-48
• Buprenorphine
• Buprenorphine-3-glucuronide
• Cyprenorphine
• Dihydroetorphine
• Etorphine
• Homprenorphine
• 18,19-Dehydrobuprenorphine (HS-599) https://www.scribd.com/doc/38715674/Synthesis-and-Pharmacological-Evaluation-of-18-19-Dehydrobuprenorphine-Heterocycles-2001-54-989-998-DOI-10-3987-COM-00-S-I-46-http-dx-doi-o https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572965/figure/fig1
• N-cyclopropylmethylnoretorphine https://www.scribd.com/doc/38098680/Proposal-for-the-Biologically-Active-Conformation-of-Opiates-and-Enkephalin-Proc-Natl-Acad-Sci-USA-Vol-74-No-11-Pg-5179-5183-Nov-1977
• Nepenthone https://pubchem.ncbi.nlm.nih.gov/substance/3727326 https://web.archive.org/web/20130619081521/http://www.ourchemical.com/catalogs_46/464-66-4.html
• Norbuprenorphine
• Norbuprenorphine-3-glucuronide
• Thevinone https://www.ncbi.nlm.nih.gov/pccompound?cmd=search&term=84879
• Thienorphine https://www.scribd.com/doc/40573109/Synthesis-and-Crystal-Structure-of-17-Allyl-4-5-anhydro-7%CE%B1-R-1-hydroxy-1-methyl-3-2-thienyl-propyl-6-methoxy-6-14-ethanomorphinan-3-4-5-triol-Th
• TH-030418

Phenazepanes

• Ethoheptazine
• Meptazinol
• Metheptazine
• Metethoheptazine
• Proheptazine

Pirinitramides

• Bezitramide
• Piritramide

Benzimidazoles

• Clonitazene
• Etonitazene
• Isotonitazene
• Metonitazene

Indoles

• 18-Methoxycoronaridine
• 7-Acetoxymitragynine 
• 7-Hydroxymitragynine
• ψ-Akuammigine
• Akuammidine 
• Akuammine
• Coronaridine
• Eseroline
• Hodgkinsine
• Ibogaine
• Mitragynine
• Mitragynine pseudoindoxyl
• Noribogaine
• Pericine
• Pseudoakuammigine

Beta-Amino Ketones

• 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one

Diphenylmethylpiperazines

• BW373U86
• DPI-221
• DPI-287
• DPI-3290
• SNC-80
• AZD-2327

Opioid peptides

Dynorphins

• Big dynorphin
• Dynorphin A
• Dynorphin B
• Leumorphin

Endomorphins

• Endomorphin-1
• Endomorphin-2

Endorphins

• α-Endorphin
• β-Endorphin
• γ-Endorphin
• α-Neoendorphin
• β-Neoendorphin

Enkephalins

• DADLE
• DAMGO
• Deltorphin 
• Met-enkephalin
• Leu-enkephalin

Propeptides

• Proenkephalin
• Proendorphin
• Proopiomelanocortin

Others / unknown

• Adrenorphin
• Amidorphin
• Biphalin
• Casokefamide
• Casomorphins
• Cytochrophin-4
• DALDA (Tyr-D-Arg-Phe-Lys-NH₂)https://www.ncbi.nlm.nih.gov/pubmed/11860345
• Deltorphin I
• Deltorphin II
• Deprolorphin
• Dermorphin
• DPDPE 
• Frakefamide
• Gliadorphin
• Gluten exorphins
• Hemorphin-4
• Metkefamide
• Morphiceptin
• Nociceptin
• Octreotide
• Opiorphin
• Rubiscolin
• Soymorphins
• Spinorphin
• TRIMU 5
• Tynorphin
• Valorphin
• Zyklophin

Others

• 3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane 
• AD-1211
• AH-7921
• Axomadol
• Azaprocin
• BDPC
• Bisnortilidine  https://www.ncbi.nlm.nih.gov/pccompound?cmd=search&term=162740 https://web.archive.org/web/20120606022318/http://www.chembase.com/cbid_162740.htm
• BRL-52537
• Bromadol
• Bromadoline
• Ciprefadol
• Ciramadol
• Doxpicomine
• Enadoline
• Faxeladol
• GR-89696
• Herkinorin
• ICI-199,441
• ICI-204,448
• Ketamine
• KNT-42
• LPK-26
• Lufuradom
• Metofoline
• MT-45
• Desmethylclozapine
• Nexeridine
• NNC 63-0532
• Nortilidine
• O-Desmethyltramadol
• Phenadone
• Phencyclidine
• Prodilidine
• Profadol
• Ro64-6198
• Salvinorin A
• Salvinorin B ethoxymethyl ether
• Salvinorin B methoxymethyl ether
• SB-612,111
• SC-17599
• RWJ-394,674
• TAN-67
• Tapentadol
• Thiobromadol (C-8813)
• Tifluadom
• Tilidine
• Tramadol
• Trimebutine
• U-47700
• U-50,488
• U-69,593
• Viminol
• 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18)

Opioid antagonists and inverse agonists

• 4-Caffeoyl-1,5-quinide
• 5'-Guanidinonaltrindole
• β-Funaltrexamine
• 6β-Naltrexol
• 6β-Naltrexol-d4
• Alvimopan
• AT-076
• Binaltorphimine
• BU09059
• Buprenorphine
• Chlornaltrexamine
• Clocinnamox
• Cyclazocine
• Cyprodime
• Diacetylnalorphine https://pubchem.ncbi.nlm.nih.gov/compound/00631837
• Diprenorphine (M5050)
• Fedotozine
• ICI-174864
• J-113,397
• JDTic
• JTC-801
• Levallorphan
• LY-2456302
• LY-255582
• Methocinnamox
• Methylnaltrexone
• ML350
• Naldemedine
• Nalfurafine
• Nalmefene
• Nalmexone https://www.ncbi.nlm.nih.gov/pccompound?cmd=search&term=5360516
• Nalodeine (N-allylnorcodeine) http://www.tradingchem.com/Search/56195-50-7.html
• Naloxazone
• Naloxegol
• Naloxol
• Naloxonazine
• Naloxone
• Naloxone benzoylhydrazone
• Nalorphine
• Naltrexone
• Naltriben
• Naltrindole
• Norbinaltorphimine
• Oxilorphan
• PF-4455242
• S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)https://pubchem.ncbi.nlm.nih.gov/compound/5487397
• Samidorphan 
• SR-16430

Biased ligands

• 6'-Guanidinonaltrindole
• 7-Hydroxymitragynine
• Herkinorin
• ICI-199,441
• Noribogaine
• Oliceridine
• RB-64
• TRV734
• SR-17018
• SR-14968

Receptor heteromer targeting ligands

• 6'-GNTI (δ-κ)
• CYM-51010 (δ-μ)
• NNTA (κ-μ)
• IBNtxA (μ1G-NOP)

Uncategorized opioids

• ADL-5859
• Alimadol
• Amentoflavone
• Anilopam +HCl
• Asimadoline
• Cyproterone acetate
• FE 200665
• Fedotozine
• HZ-2
• Kolokol-1
• Matrine
• MCOPPB
• Menthol
• MT-7716
• Nalfurafine
• Nalorphine
• Nalorphine dinicotinate
• PZM21
• Proglumide
• Ro65-6570 
• SoRI-9409 
• Spiradoline 
• SR-8993 
• SR-16435

Combination drug formulations containing opioids

• Buprenorphine/naloxone
• Buprenorphine/samidorphan (ALKS-5461)
• Co-codamol (codeine phosphate/paracetamol)
• Co-codaprin (codeine phosphate/aspirin)
• Co-dydramol (dihydrocodeine tartrate/paracetamol)
• Co-proxamol (dextropropoxyphene/paracetamol)
• Fentanyl/fluanisone
• Hydrocodone/ibuprofen
• Hydrocodone/paracetamol
• Loperamide/simethicone
• Morphine/naltrexone
• Naltrexone/bupropion
• Oxycodone/aspirin
• Oxycodone/naloxone
• Oxycodone/paracetamol

See also

• List of opioids by visual 2D molecular skeletal renderings (bundled remotely, click "show" after following link)
• List of Schedule I drugs (US)
• Gray death

References

External links

• Carbonate derivatives of 14β-hydroxycodeine <small>"viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time."</small> Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp.&nbsp;1739–1740