C-8813 (thiobromadol) is a potent ü-opioid receptor agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans-isomer was found to be around 591 times more potent than morphine in animal studies. The same study assigned a potency of 504 times that of morphine to the related compound BDPC.
C-8813 is claimed to be similarly potent at the ô-opioid receptor, which antagonizes the ü-induced depression of breathing, presumably making the drug safer.
C-8813 has never been approved for use in humans.