DADLE ([<small>D</small>-Ala<sup>2</sup>, <small>D</small>-Leu<sup>5</sup>]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective ô-opioid receptor agonist, it also binds to the ü<sub>1</sub> subtype of ü-opioid receptors.
Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.
Its peptide sequence is Tyr-<small>D</small>-Ala-Gly-Phe-<small>D</small>-Leu.