The Letichev uezd was a county (uezd) of the Podolian Governorate of the Russian Empire. The uezd bordered the Starokonstantinov uezd of the Volhynian Governorate, the Litin uezd to the east, the Mogilev uezd to the southeast, the Ushitsa uezd to the south, and the Proskurov uezd to the west. The area of the uezd encompassed most of Khmelnytskyi Raion of Ukraine. The administrative centre of the county was Letichev (contemporary Letychiv).
The subcounties (volosts) of the Letichev uezd in 1912 were as follows:
At the time of the Russian Empire Census on , the Letichev uezd had a population of 184,477, including 92,618 men and 91,859 women. The majority of the population indicated Little Russian to be their mother tongue, with a significant Jewish speaking minority.