The Litin uezd was a county (uezd) of the Podolian Governorate of the Russian Empire. The uezd bordered the Novograd-Volynsky and Zhitomir uezds of the Volhynian Governorate to the north, the Vinnitsa uezd to the east, the Mogilev uezd to the south, and the Ushitsa uezd to the west. It composed most of Vinnytsia Raion. The administrative centre of the county was Litin (modern-day Lityn).
The subcounties (volosts) of the Litin uezd in 1912 were as follows:
At the time of the Russian Empire Census on , the Litin uezd had a population of 210,502, including 104,182 men and 106,320 women. The majority of the population indicated Little Russian to be their mother tongue, with a significant Jewish speaking minority.