2CBecca, also known as 4-(4-bromo-2,5-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline, is a serotonin receptor modulator of the phenethylamine, 2C, and N-benzylphenethylamine families. It is a cyclized phenethylamine analogue of the serotonergic psychedelic 25B-NBOMe in which the N-benzylethylamine side chain has been cyclized to form a tetrahydroisoquinoline ring. The drug shows affinity for the serotonin 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptors (K<sub>i</sub> = 39âÂÂ71nM and 267âÂÂ850nM, respectively). 2CBecca was first described in the scientific literature by Michael Robert Braden of the lab of David E. Nichols at Purdue University in 2007.