Z3517967757, or simply Z7757, is a 3-phenylpiperidine derivative which acts as an agonist at the 5-HT<sub>2</sub> family of serotonin receptors, first reported in 2024. It can also be viewed as a ring-restrained phenethylamine. It has strongest activity at the 5-HT<sub>2A</sub> receptor and lower affinity at the 5-HT<sub>2B</sub> and 5-HT<sub>2C</sub> receptors. However, it has been reported to have excellent selectivity for the 5-HT<sub>2A</sub> receptor, with no agonistic activity at the 5-HT<sub>2B</sub> and 5-HT<sub>2C</sub> receptors. The drug was developed using in silico modelling to dock a large library of compounds against a 5-HT<sub>2A</sub> receptor model generated by the artificial intelligence program AlphaFold, and then synthesised and tested in the laboratory to confirm activity. It has two stereogenic centers and four possible isomers, but has only been tested as a racemic mixture.