IHCH-7079 is a non-hallucinogenic serotonin 5-HT<sub>2A</sub> receptor biased agonist of the pyridopyrroloquinoxaline family. It was derived via structural simplification of the serotonin 5-HT<sub>2A</sub> receptor antagonist and atypical antipsychotic lumateperone. The drug produces antidepressant-like effects but not psychedelic-like effects in rodents. Other related compounds include IHCH-7086, which is a non-hallucinogenic serotonin 5-HT<sub>2A</sub> receptor biased agonist similarly, and IHCH-7113, which produces the head-twitch response in rodents and hence would be expected to be hallucinogenic in humans.