L-iditol 2-dehydrogenase

In enzymology, a L-iditol 2-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are L-iditol and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are L-sorbose, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-iditol:NAD⁺ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD⁺ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD⁺ oxidoreductase, NAD⁺-dependent sorbitol dehydrogenase, NAD⁺-dependent sorbitol dehydrogenase, and NAD⁺-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .

See also

• D-iditol 2-dehydrogenase

References