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Ketopantoic acid

Ketopantoic acid is the organic compound with the formula HOCH<sub>2</sub>(CH<sub>3</sub>)<sub>2</sub>CC(O)CO<sub>2</sub>H. At physiological conditions, ketopantoic acid exists as its conjugate base, ketopantoate (HOCH<sub>2</sub>(CH<sub>3</sub>)<sub>2</sub>CC(O)CO<sub>2</sub><sup>−</sup>).

Biosynthetic context

Its biosynthesis proceeds from ketoisovalerate by hydroxymethylation:

(CH<sub>3</sub>)<sub>2</sub>CHC(O)CO<sub>2</sub><sup>−</sup> + CH<sub>2</sub>O → HOCH<sub>2</sub>(CH<sub>3</sub>)<sub>2</sub>CC(O)CO<sub>2</sub><sup>−</sup>

This conversion is catalyzed by ketopantoate hydroxymethyltransferase, which gives ketopantoate.

Ketopantoate is substrate for 2-dehydropantoate 2-reductase, which produces (R)-pantoic acid, a precursor to pantothenic acid, a common prosthetic group.

References