Cinobufotenine, also known as bufotenium, bufoteninium, or 5-hydroxy-N,N,N-trimethyltryptaminium, is a quaternary ammonium cation as well as a derivative of 5-hydroxytryptamine, It is the parent compound for bufotenidine. The compound is a powerful stimulant of the parasympathetic ganglia, activates nicotine-sensitive acetylcholine receptors, ÃÂinobufotenine is highly active on the ileum.
It is similar to bufotenidine in that it does not readily cross the blood-brain barrier and is therefore peripherally selective. Cinobufotenine has very little activity or low affinity at the 5-hydroxytryptamine receptor, possessing less than one thousandth the potency of 5-hydroxytryptamine. and also has a stimulation of cardiac activity, ten times less than the activity of adrenaline chloride, has a low miotic effect and increases the tone of the isolated intestine and uterus.
Contained within the skin of certain toads (Bufo gargarizans).