The Yampol uezd was a county (uezd) of the Podolia Governorate of the Russian Empire. It bordered the Vinnitsa uezd to the north, the Bratslav and Olgopol uezds to the east, the Soroka uezd to the south, and the Mogilev uezd to the west. The district was eponymously named for its administrative center, Yampol (modern-day Yampil).
The subcounties (volosts) of the Yampol uezd in 1912 were as follows:
At the time of the Russian Empire Census on , the Yampol uezd had a population of 266,300, including 131,330 men and 134,970 women. The majority of the population indicated Little Russian to be their mother tongue, with a significant Jewish speaking minority.