William Clayton may refer to:
Politics
United Kingdom
- William Clayton (Liverpool MP) (died 1715), Member of Parliament for Liverpool, 1698âÂÂ1708
- Sir William Clayton, 1st Baronet (died 1744), Member of Parliament for Bletchingley, 1715âÂÂ1744
- William Clayton, 1st Baron Sundon (1671âÂÂ1752), MP for Woodstock, St Albans, Westminster, Plympton Erle and St Mawes
- William Clayton (died 1783) (c. 1718âÂÂ1783), MP for Bletchingley, 1745âÂÂ1761, and Great Marlow, 1761âÂÂ1783
- Sir William Clayton, 4th Baronet (1762âÂÂ1834), Member of Parliament for Great Marlow, 1783âÂÂ1790
- Sir William Clayton, 5th Baronet (1786âÂÂ1866), Member of Parliament for Great Marlow, 1832âÂÂ1842
United States
- William F. Clayton (1923âÂÂ2017), US politician
- William C. Clayton (1831âÂÂ1915), American educator, lawyer, politician, and businessperson
- W. H. H. Clayton (1840âÂÂ1920), American soldier, lawyer, judge in post-Civil War Arkansas and Indian Territory Oklahoma
- William L. Clayton (1880âÂÂ1966), US assistant secretary of state for economic affairs
- William Clayton (colonist) (1632âÂÂ1689), acting Governor of the Pennsylvania Colony, 1684âÂÂ1685
- William Wirt Clayton (1812âÂÂ1885), judge, director and tax collector in Atlanta, Georgia
- William M. Clayton (1824âÂÂ?), US politician, mayor of Denver, Colorado, 1868âÂÂ1869
Other
See also