William F. Clayton (September 20, 1923 – April 20, 2017) was an American politician and U.S. Attorney for District of South Dakota.
Clayton graduated from the University of South Dakota School of Law in 1951.
He was a member of the South Dakota House of Representatives. He was a veteran of World War II, with the United States Army. He was later an attorney. He was the United States Attorney for the District of South Dakota from 1969 until 1977.