William Christoph of Hesse-Homburg (13 November 1625, Ober-Rosbach â 27 August 1681, then in Bingenheim, now in Echzell) was the second Landgrave of Hesse-Homburg (then known as "Landgrave of Bingenheim") from 1648 to 1669.
He was the third but second surviving of five sons of Frederick I, Landgrave of Hesse-Homburg and succeeded his brother Ludwig I as Landgrave in 1643, but his mother was his regent until 1648.
In 1669, he sold Homburg to his younger brother George Christian but retained Bingenheim (Landgrave of Hesse-Homburg-Bingenheim). George Christian died without heirs, and their youngest brother succeeded as Frederick II, Landgrave of Hesse-Homburg.
In Darmstadt on 21 April 1650, William Christoph married firstly Princess Sophia Eleonore, a daughter of George II, Landgrave of Hesse-Darmstadt. George II was his first cousin, as both were grandsons of George I, Landgrave of Hesse-Darmstadt. They had 12 children of which only three survived infancy:
In Lübeck on 2 April 1665, William Christoph married secondly Princess Anna Elisabeth of Saxe-Lauenburg, a daughter of Duke Augustus of Saxe-Lauenburg. They were divorced in 1672, and Anna Elisabeth retired to and later died in Philippseck Castle in today's Butzbach.