Landgravine Christine Wilhelmine of Hesse-Homburg (30 June 1653, in Bingenheim – 16 May 1722, in Grabow) was a German noblewoman, the elder daughter of William Christoph, Landgrave of Hesse-Homburg and his first wife Sophia Eleonore of Hesse-Darmstadt. Upon her marriage she became the Duchess of Mecklenburg-Grabow. Her great-grandson was Ivan VI of Russia.
On 28 May 1671 she married Frederick, Duke of Mecklenburg-Grabow, son of Adolf Frederick I, Duke of Mecklenburg and Marie Katharina of Brunswick-Dannenberg. They had the following children: