Wilcox is an unincorporated community in Gilchrist County, Florida, United States. It is located about west of Lottieville, at the bend in State Road 26.
Wilcox is located at , its elevation .
Wilcox was the westernmost stop on the Atlantic Coast Line Railroad JacksonvilleâÂÂWilcox Line, before that line connected to a wye at Wilcox Junction with the Atlantic Coast Line Railroad ThomasvilleâÂÂDunnellon Line. Today, all three legs of this wye are used by the Nature Coast State Trail.