West Branch Louse Creek is a long second-order tributary to Louse Creek in Holt County, Nebraska. The confluence of this creek with East Branch Louse Creek forms Louse Creek.
West Branch Louse Creek rises on the North Branch Verdigre Creek divide about northwest of Opportunity, Nebraska in Holt County and then flows northeast to join East Branch Louse Creek forming Louse Creek about west of Dorsey, Nebraska.
West Branch Louse Creek drains of area, receives about of precipitation, and is about 0.07% forested.