Louse Creek is a long third-order tributary to the Niobrara River in Holt County, Nebraska.
Louse Creek begins at the confluence of East and West Branches of Louse Creek about west of Dorsey, Nebraska in Holt County and then flows generally north-northwest to join the Niobrara River about north-northeast of Redbird, Nebraska.
Louse Creek drains of area, receives about of precipitation, and is about 4.18% forested.