The vice governor of Santa Fe Province () is the second-highest position in the executive branch of the government of Santa Fe Province, Argentina, after the governor, and ranks first in the state's governmental succession.
It has the function of replacing the governor in case of travel abroad or impediments and to succeed him in case of resignation, death or removal from office by specific process. To be vice-governor it is necessary to be Argentine born and to be at least 30 years old, and to prove two years of immediate residence in the province if the prospective candidate was not born there.
The last person to hold the position was Gisela Scaglia, who resigned. Currently, the vice-governorship is vacant from December 9, 2025. Unofficially, Felipe Michlig, as the pro tempore president of the Senate of Santa Fe, would be next in line to assume the governorship in the event of a government vacancy, since there is no designated vice-governor.
Article 70 of the Constitution of Santa Fe states that:
Article 66 states the following:
Article 71: