Van Slyke or Van Slycke is a Dutch toponymic surname meaning "of/from Slyke". The Dictionary of American Family Names published by Oxford University Press documents the two most likely meanings of the word "Slyke" here:
- from Middle Dutch slijcke "mire", "marshy place" (modern Dutch )
- from a place named after this word, such as Slijkenburg in Friesland, Slijkewijck in Gelderland or possibly Slik in North Holland
People with the surname Van Slyke
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