Slijkenburg () is a village in Weststellingwerf in the province of Friesland, the Netherlands. It had a population of around 36 in 2017.
It is the southernmost village of Friesland, located at the Overijssel provincial border.
The village was first mentioned in 1398 as Slickenborg; its name refers to a borg on silted soil.
In 1580, a sluice was built in Slijkenburg. In 1672, a sconce was built around the village to protect against the Prince-Bishop of Münster. Slijkenburg was home to 68 people in 1840.