Turkey Creek is a long first-order tributary to the Niobrara River in Holt County, Nebraska.
Turkey Creek rises on the Brush Creek and Elkhorn River divides about southeast of School No. 147 in Holt County and then flows generally north-northeast to join the Niobrara River about east of Anncar, Nebraska.
Turkey Creek drains of area, receives about of precipitation, and is about 5.59% forested.