Brush Creek is a long second-order tributary to the Niobrara River in Holt County, Nebraska.
Brush Creek rises on the North Branch Eagle Creek divide about northeast of School No. 89 in Holt County and then flows generally north-northeast to join the Niobrara River about northwest of School No. 12.
Brush Creek drains of area, receives about of precipitation, and is about 2.80% forested.